Co-director William Hanna provided most of the squeaks, gasps, and other vocal effects for the pair, including the most famous sound effects from the series, Tom's leather-lunged scream created by recording Hanna's scream and eliminating the beginning and ending of the recording, leaving only the strongest part of the scream on the soundtrack and Jerry's nervous gulp.
Usually, Jerry does eventually wreck whatever Spike is doing in spectacular fashion and leaves Tom to take the blame, forcing him to flee from Spike and inevitably lose usually because Tom is usually framed by Jerry and that Spike just doesn't like Tom.